Version 5.4
Homo sapiens Protein: KCNAB2
Summary
InnateDB Protein IDBP-87200.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNAB2
Protein Name potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2;
Species Homo sapiens
Ensembl Protein ENSP00000318772
InnateDB Gene IDBG-87190 (KCNAB2)
Protein Structure
UniProt Annotation
Function Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.4. {ECO:0000269PubMed:7649300}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0044224 juxtaparanode region of axon
Protein Structure and Domains
PDB ID
InterPro IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
IPR005401 Potassium channel, voltage-dependent, beta subunit, KCNAB2
IPR005402 Potassium channel, voltage-dependent, beta subunit, KCNAB3
IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS PR01577
PR01578
PR01579
PR01580
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13303
PhosphoSite PhosphoSite-Q13303
TrEMBL Q5TG80
UniProt Splice Variant
Entrez Gene 8514
UniGene Hs.735032
RefSeq NP_742128
HUGO HGNC:6229
OMIM 601142
CCDS CCDS56
HPRD 03090
IMGT
EMBL AF029749 AF044253 AK124696 AK131252 AK289819 AK315858 AL035406 BC126424 BC130413 U33429
GenPept AAB84170 AAB99859 AAC50955 AAI26425 AAI30414 BAD18431 BAF82508 BAF98749 BAG54071 CAC08512 CAI19885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca