InnateDB Protein
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IDBP-87655.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD40LG
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Protein Name
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CD40 ligand
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Synonyms
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CD154; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359663
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InnateDB Gene
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IDBG-87653 (CD40LG)
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Protein Structure
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Function |
Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269PubMed:15193700}.Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269PubMed:15193700}.
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Subcellular Localization |
Cell membrane; Single-pass type II membrane protein.CD40 ligand, soluble form: Secreted.
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Disease Associations |
X-linked immunodeficiency with hyper-IgM 1 (HIGM1) [MIM:308230]: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. {ECO:0000269PubMed:7532185, ECO:0000269PubMed:7678782, ECO:0000269PubMed:7679206, ECO:0000269PubMed:7679801, ECO:0000269PubMed:7717401, ECO:0000269PubMed:8094231, ECO:0000269PubMed:8550833, ECO:0000269PubMed:8889581, ECO:0000269PubMed:9150729, ECO:0000269PubMed:9746782}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Specifically expressed on activated CD4+ T- lymphocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
8
[view]
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Protein-RNA |
2
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003263
Tumour necrosis factor ligand 5
IPR006052
Tumour necrosis factor domain
IPR008983
Tumour necrosis factor-like domain
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PFAM |
PF00229
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PRINTS |
PR01702
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PIRSF |
PIRSF016527
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SMART |
SM00207
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TIGRFAMs |
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Modification |
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SwissProt |
P29965
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PhosphoSite |
PhosphoSite-P29965
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TrEMBL |
Q3LFI8
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UniProt Splice Variant |
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Entrez Gene |
959
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UniGene |
Hs.592244
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RefSeq |
NP_000065
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HUGO |
HGNC:11935
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OMIM |
300386
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CCDS |
CCDS14659
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HPRD |
02311
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IMGT |
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EMBL |
AF529195
BC071754
BC074950
D31797
L07414
X67878
X68550
Z15017
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GenPept |
AAA35662
AAH71754
AAH74950
AAQ09090
BAA06599
CAA48077
CAA48554
CAA78737
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