InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD40LG

Summary

InnateDB Gene

IDBG-87653.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD40LG

Gene Name

CD40 ligand

Synonyms

CD154; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP;

Species

Homo sapiens

Ensembl Gene

ENSG00000102245

Encoded Proteins

IDBP-87655

CD40 ligand

IDBP-87657

CD40 ligand

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:136648193-136660390

Strand

Forward strand

Band

q26.3

Transcripts

ENST00000370629	ENSP00000359663
ENST00000370628	ENSP00000359662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	13 [view]
Protein-DNA	8 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005174	CD40 receptor binding
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007159	leukocyte cell-cell adhesion
GO:0030168	platelet activation
GO:0030183	B cell differentiation
GO:0032735	positive regulation of interleukin-12 production
GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045190	isotype switching
GO:0048305	immunoglobulin secretion
GO:0050776	regulation of immune response
GO:0051023	regulation of immunoglobulin secretion
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000031132

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000017843

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_11152

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04660

T cell receptor signaling pathway pathway

hsa04672

Intestinal immune network for IgA production pathway

hsa05144

Malaria pathway

hsa05145

Toxoplasmosis pathway

hsa05310

Asthma pathway

hsa05320

Autoimmune thyroid disease pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05330

Allograft rejection pathway

hsa05340

Primary immunodeficiency pathway

hsa05416

Viral myocarditis pathway

INOH

INOH website

GPCR signaling pathway

INOH website

JAK STAT pathway and regulation pathway

PID BIOCARTA

100213

Cd40l signaling pathway [Biocarta view]

PID NCI

cd40_pathway

CD40/CD40L signaling

tcrcalciumpathway

Calcium signaling in the CD4+ TCR pathway

integrin2_pathway

Beta2 integrin cell surface interactions

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

il4_2pathway

IL4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.592244

RefSeq

NM_000074

HUGO

OMIM

CCDS

CCDS14659

HPRD

02311

IMGT

EMBL

GenPept

RNA Seq Atlas