Homo sapiens Gene: CD40LG
Summary
InnateDB Gene IDBG-87653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD40LG
Gene Name CD40 ligand
Synonyms CD154; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP;
Species Homo sapiens
Ensembl Gene ENSG00000102245
Encoded Proteins
CD40 ligand
CD40 ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:136648193-136660390
Strand Forward strand
Band q26.3
Transcripts
ENST00000370629 ENSP00000359663
ENST00000370628 ENSP00000359662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 13 [view]
Protein-DNA 8 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007159 leukocyte cell-cell adhesion
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0032735 positive regulation of interleukin-12 production
GO:0042100 B cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045190 isotype switching
GO:0048305 immunoglobulin secretion
GO:0050776 regulation of immune response
GO:0051023 regulation of immunoglobulin secretion
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Cell adhesion molecules (CAMs) pathway
T cell receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Malaria pathway
Toxoplasmosis pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Primary immunodeficiency pathway
Viral myocarditis pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Cd40l signaling pathway [Biocarta view]
PID NCI
CD40/CD40L signaling
Calcium signaling in the CD4+ TCR pathway
Beta2 integrin cell surface interactions
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592244
RefSeq NM_000074
HUGO
OMIM
CCDS CCDS14659
HPRD 02311
IMGT
EMBL
GenPept
RNA Seq Atlas