InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBMX

Summary

InnateDB Protein

IDBP-87734.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBMX

Protein Name

RNA binding motif protein, X-linked

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359645

InnateDB Gene

IDBG-87732 (RBMX)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269PubMed:12165565, ECO:0000269PubMed:12761049, ECO:0000269PubMed:16707624, ECO:0000269PubMed:18445477, ECO:0000269PubMed:18541147, ECO:0000269PubMed:19282290, ECO:0000269PubMed:21327109}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19282290, ECO:0000269PubMed:21327109}. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.

Disease Associations

Tissue Specificity

Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). {ECO:0000269PubMed:16707624}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.

Experimentally validated
Total	110 [view]
Protein-Protein	110 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001047	core promoter binding
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006509	membrane protein ectodomain proteolysis
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0048026	positive regulation of mRNA splicing, via spliceosome
GO:0051260	protein homooligomerization
GO:0071347	cellular response to interleukin-1

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005719	nuclear euchromatin
GO:0016020	membrane
GO:0019013	viral nucleocapsid
GO:0030529	ribonucleoprotein complex
GO:0044530	supraspliceosomal complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome