InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GBF1

Summary

InnateDB Protein

IDBP-87845.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GBF1

Protein Name

golgi brefeldin A resistant guanine nucleotide exchange factor 1

Synonyms

ARF1GEF;

Species

Homo sapiens

Ensembl Protein

ENSP00000359000

InnateDB Gene

IDBG-87843 (GBF1)

Protein Structure

UniProt Annotation

Function

Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0006892	post-Golgi vesicle-mediated transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0032012	regulation of ARF protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0048205	COPI coating of Golgi vesicle
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005801	cis-Golgi network
GO:0005802	trans-Golgi network
GO:0016020	membrane