Version 5.4
Homo sapiens Gene: GBF1
Summary
InnateDB Gene IDBG-87843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBF1
Gene Name golgi brefeldin A resistant guanine nucleotide exchange factor 1
Synonyms ARF1GEF
Species Homo sapiens
Ensembl Gene ENSG00000107862
Encoded Proteins
IDBP-87845
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:102245532-102382899
Strand Forward strand
Band q24.32
Transcripts
ENST00000369983 ENSP00000359000
ENST00000476019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006892 post-Golgi vesicle-mediated transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048205 COPI coating of Golgi vesicle
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005801 cis-Golgi network
GO:0005802 trans-Golgi network
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025224
View Gene Order
ENSBTAG00000006014
Not yet available
Pathways
NETPATH
REACTOME
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11096
COPI Mediated Transport pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11208
Golgi to ER Retrograde Transport pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt Q92538
TrEMBL Q149P0
UniProt Splice Variant
Entrez Gene 8729
UniGene Hs.290243
RefSeq NM_001199378 NM_001199379 NM_004193 XM_005270261
HUGO HGNC:4181
OMIM 603698
CCDS CCDS7533
HPRD
IMGT
EMBL AF068755 AL121928 AL160011 AL356420 BC007941 BC014171 BC117682 D87435
GenPept AAD15903 AAH07941 AAH14171 AAI17683 BAA13379 CAH71625 CAH72761 CAI12515
RNA Seq Atlas 8729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca