Homo sapiens Gene: GBF1
Summary
InnateDB Gene IDBG-87843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBF1
Gene Name golgi brefeldin A resistant guanine nucleotide exchange factor 1
Synonyms ARF1GEF;
Species Homo sapiens
Ensembl Gene ENSG00000107862
Encoded Proteins
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:102245532-102382899
Strand Forward strand
Band q24.32
Transcripts
ENST00000369983 ENSP00000359000
ENST00000476019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006892 post-Golgi vesicle-mediated transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048205 COPI coating of Golgi vesicle
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005801 cis-Golgi network
GO:0005802 trans-Golgi network
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
COPI Mediated Transport pathway
Golgi to ER Retrograde Transport pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
PID NCI
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.290243
RefSeq NM_001199378 NM_001199379 NM_004193 XM_005270261
HUGO
OMIM
CCDS CCDS7533
HPRD 04740
IMGT
EMBL
GenPept
RNA Seq Atlas