InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2I

Summary

InnateDB Protein

IDBP-8786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2I

Protein Name

ubiquitin-conjugating enzyme E2I

Synonyms

C358B7.1; P18; UBC9;

Species

Homo sapiens

Ensembl Protein

ENSP00000324897

InnateDB Gene

IDBG-8784 (UBE2I)

Protein Structure

UniProt Annotation

Function

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269PubMed:11451954, ECO:0000269PubMed:15809060, ECO:0000269PubMed:17466333, ECO:0000269PubMed:19638400, ECO:0000269PubMed:19744555, ECO:0000269PubMed:20077568, ECO:0000269PubMed:8668529}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. {ECO:0000269PubMed:8610150}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 382 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	382 [view]
Protein-Protein	380 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0016032	viral process
GO:0016925	protein sumoylation
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045892	negative regulation of transcription, DNA-templated