Homo sapiens Protein: ODF2
Summary
InnateDB Protein IDBP-88094.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ODF2
Protein Name outer dense fiber of sperm tails 2
Synonyms CT134; ODF2/1; ODF2/2; ODF84;
Species Homo sapiens
Ensembl Protein ENSP00000361901
InnateDB Gene IDBG-88092 (ODF2)
Protein Structure
UniProt Annotation
Function Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269PubMed:16966375}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.
Disease Associations
Tissue Specificity Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails. {ECO:0000269PubMed:10381817}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007275 multicellular organismal development
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BJF6
PhosphoSite PhosphoSite-Q5BJF6
TrEMBL Q9UNM2
UniProt Splice Variant
Entrez Gene 4957
UniGene Hs.129055
RefSeq NP_702917
HUGO HGNC:8114
OMIM 602015
CCDS CCDS56586
HPRD 03601
IMGT
EMBL AF012549 AF053970 AF109138 AK299303 AK301842 AK302684 AL359091 AL445287 AY319414 AY366499 BC010629 BC091500 CH471090 DQ444713 DQ444714
GenPept AAB66337 AAC08409 AAD22544 AAH10629 AAH91500 AAP83847 AAQ73195 ABE01856 ABE01857 BAG61316 BAG63285 BAG63914 CAH71066 CAH71067 CAH71069 CAI13499 CAI13500 CAI13506 EAW87791 EAW87793 EAW87795