InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ODF2

Summary

InnateDB Protein

IDBP-88096.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODF2

Protein Name

outer dense fiber of sperm tails 2

Synonyms

CT134; ODF2/1; ODF2/2; ODF84;

Species

Homo sapiens

Ensembl Protein

ENSP00000342581

InnateDB Gene

IDBG-88092 (ODF2)

Protein Structure

UniProt Annotation

Function

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269PubMed:16966375}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.

Disease Associations

Tissue Specificity

Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails. {ECO:0000269PubMed:10381817}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.