InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR1C

Summary

InnateDB Protein

IDBP-88358.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR1C

Protein Name

polymerase (RNA) I polypeptide C, 30kDa

Synonyms

RPA39; RPA40; RPA5; RPAC1; TCS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000361465

InnateDB Gene

IDBG-88354 (POLR1C)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Treacher Collins syndrome 3 (TCS3) [MIM:248390]: A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. {ECO:0000269PubMed:21131976}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response

Cellular Component

GO:0005654	nucleoplasm
GO:0005666	DNA-directed RNA polymerase III complex
GO:0005736	DNA-directed RNA polymerase I complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain
IPR011262 DNA-directed RNA polymerase, insert domain
IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type

PFAM

PF01193
PF01000

PRINTS

PIRSF

SMART

SM00662

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15160