Homo sapiens Gene: POLR1C
Summary
InnateDB Gene IDBG-88354.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR1C
Gene Name polymerase (RNA) I polypeptide C, 30kDa
Synonyms RPA39; RPA40; RPA5; RPAC1; TCS3;
Species Homo sapiens
Ensembl Gene ENSG00000171453
Encoded Proteins
polymerase (RNA) I polypeptide C, 30kDa
polymerase (RNA) I polypeptide C, 30kDa
polymerase (RNA) I polypeptide C, 30kDa
polymerase (RNA) I polypeptide C, 30kDa
polymerase (RNA) I polypeptide C, 30kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43509702-43529585
Strand Forward strand
Band p21.1
Transcripts
ENST00000304004 ENSP00000307212
ENST00000372389 ENSP00000361465
ENST00000372344 ENSP00000361419
ENST00000423780 ENSP00000409536
ENST00000455605
ENST00000428025 ENSP00000395401
ENST00000481352
ENST00000512472
ENST00000488601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response
Cellular Component
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
RNA Polymerase I Transcription pathway
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase III Transcription Termination pathway
Innate Immune System pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase III Chain Elongation pathway
Immune System pathway
RNA Polymerase III Transcription pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Cytosolic sensors of pathogen-associated DNA pathway
Gene Expression pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
Negative epigenetic regulation of rRNA expression pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA polymerase pathway
Cytosolic DNA-sensing pathway pathway
INOH
PID BIOCARTA
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632895
RefSeq NM_203290 XM_005249491
HUGO
OMIM
CCDS CCDS4901
HPRD 09661
IMGT
EMBL
GenPept
RNA Seq Atlas