InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCM1

Summary

InnateDB Protein

IDBP-8870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCM1

Protein Name

pericentriolar material 1

Synonyms

PTC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000327077

InnateDB Gene

IDBG-8866 (PCM1)

Protein Structure

UniProt Annotation

Function

Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. {ECO:0000269PubMed:12403812, ECO:0000269PubMed:15659651, ECO:0000269PubMed:16943179, ECO:0000269PubMed:20551181, ECO:0000269PubMed:24121310}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruitement to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling.

Disease Associations

Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving PCM1 is found in thyroid papillary carcinomas. Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1.Note=A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1.

Tissue Specificity

Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid. {ECO:0000269PubMed:10980597, ECO:0000269PubMed:15184884, ECO:0000269PubMed:16270321, ECO:0000269PubMed:16424865}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	56 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0022027	interkinetic nuclear migration
GO:0031122	cytoplasmic microtubule organization
GO:0034453	microtubule anchoring
GO:0034454	microtubule anchoring at centrosome
GO:0035735	intraciliary transport involved in cilium morphogenesis
GO:0042384	cilium assembly
GO:0050768	negative regulation of neurogenesis
GO:0051297	centrosome organization
GO:0071539	protein localization to centrosome
GO:0090316	positive regulation of intracellular protein transport
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0043234	protein complex