Homo sapiens Gene: PCM1
Summary
InnateDB Gene IDBG-8866.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCM1
Gene Name pericentriolar material 1
Synonyms PTC4;
Species Homo sapiens
Ensembl Gene ENSG00000078674
Encoded Proteins
pericentriolar material 1
pericentriolar material 1
pericentriolar material 1
pericentriolar material 1
pericentriolar material 1
pericentriolar material 1
pericentriolar material 1
pericentriolar material 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:17922840-18029944
Strand Forward strand
Band p22
Transcripts
ENST00000325083 ENSP00000327077
ENST00000327578 ENSP00000328332
ENST00000518930
ENST00000517545
ENST00000517730 ENSP00000428131
ENST00000518537 ENSP00000428123
ENST00000518936
ENST00000523055 ENSP00000429941
ENST00000519253 ENSP00000431099
ENST00000524226 ENSP00000430521
ENST00000518985
ENST00000517836
ENST00000518762
ENST00000524356
ENST00000523540
ENST00000522275 ENSP00000429054
ENST00000522998
ENST00000522777
ENST00000521338
ENST00000519802
ENST00000518877
ENST00000524203
ENST00000523896
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 56 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0022027 interkinetic nuclear migration
GO:0031122 cytoplasmic microtubule organization
GO:0034453 microtubule anchoring
GO:0034454 microtubule anchoring at centrosome
GO:0035735 intraciliary transport involved in cilium morphogenesis
GO:0042384 cilium assembly
GO:0050768 negative regulation of neurogenesis
GO:0051297 centrosome organization
GO:0071539 protein localization to centrosome
GO:0090316 positive regulation of intracellular protein transport
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0034451 centriolar satellite
GO:0036064 ciliary basal body
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491148
RefSeq NM_006197 XM_005273521
HUGO
OMIM
CCDS CCDS47812
HPRD 02624
IMGT
EMBL
GenPept
RNA Seq Atlas