InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCBL1

Summary

InnateDB Protein

IDBP-88754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCBL1

Protein Name

cysteine conjugate-beta lyase, cytoplasmic

Synonyms

GTK; KAT1; KATI;

Species

Homo sapiens

Ensembl Protein

ENSP00000302227

InnateDB Gene

IDBG-88752 (CCBL1)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. {ECO:0000269PubMed:19338303}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008483	transaminase activity
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0036141	L-phenylalanine-oxaloacetate transaminase activity
GO:0042803	protein homodimerization activity
GO:0047312	L-phenylalanine:pyruvate aminotransferase activity
GO:0047316	glutamine-phenylpyruvate transaminase activity
GO:0047804	cysteine-S-conjugate beta-lyase activity
GO:0047945	L-glutamine:pyruvate aminotransferase activity

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0006569	tryptophan catabolic process
GO:0006575	cellular modified amino acid metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0070189	kynurenine metabolic process
GO:0097053	L-kynurenine catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF01053
PF00155

PRINTS

PIRSF

PIRSF001434

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16773