InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR50

Summary

InnateDB Protein

IDBP-88879.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR50

Protein Name

G protein-coupled receptor 50

Synonyms

H9; Mel1c;

Species

Homo sapiens

Ensembl Protein

ENSP00000218316

InnateDB Gene

IDBG-88877 (GPR50)

Protein Structure

UniProt Annotation

Function

Does not bind melatonin.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Hypothalamus and pituitary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008502	melatonin receptor activity
GO:0042802	identical protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000025 Melatonin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR002280 Melatonin-related receptor 1X
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00857
PR00237
PR01012
PR01151

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13585