Version 5.4
Homo sapiens Protein: CRISP1
Summary
InnateDB Protein IDBP-90313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRISP1
Protein Name cysteine-rich secretory protein 1
Synonyms AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP;
Species Homo sapiens
Ensembl Protein ENSP00000338276
InnateDB Gene IDBG-90311 (CRISP1)
Protein Structure
UniProt Annotation
Function May have a role in sperm-egg fusion and maturation.
Subcellular Localization Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head.
Disease Associations
Tissue Specificity Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
Biological Process
GO:0007339 binding of sperm to zona pellucida
GO:0007342 fusion of sperm to egg plasma membrane
GO:0060046 regulation of acrosome reaction
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001283 Cysteine-rich secretory protein, allergen V5/Tpx-1-related
IPR002413 Ves allergen
IPR013871 Cysteine-rich secretory protein
IPR014044 CAP domain
PFAM PF08562
PF00188
PRINTS PR00837
PR00838
PIRSF PIRSF038921
SMART SM00198
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P54107
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 167
UniGene Hs.109620
RefSeq NP_001122
HUGO HGNC:304
OMIM 601193
CCDS CCDS4931
HPRD 03118
IMGT
EMBL AB451334 AB451479 AL359458 D38451 S80310 X95237 X95238
GenPept AAB35899 BAA07483 BAG70148 BAG70293 CAA64524 CAA64525 CAC34980

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca