InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF3C4

Summary

InnateDB Protein

IDBP-90382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF3C4

Protein Name

general transcription factor IIIC, polypeptide 4, 90kDa

Synonyms

KAT12; TFIII90; TFIIIC290; TFIIIC90; TFIIICDELTA;

Species

Homo sapiens

Ensembl Protein

ENSP00000361219

InnateDB Gene

IDBG-90380 (GTF3C4)

Protein Structure

UniProt Annotation

Function

Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.

Experimentally validated
Total	59 [view]
Protein-Protein	56 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0006384	transcription initiation from RNA polymerase III promoter
GO:0010467	gene expression
GO:0016573	histone acetylation
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0042797	tRNA transcription from RNA polymerase III promoter
GO:0043085	positive regulation of catalytic activity