InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL17A

Summary

InnateDB Protein

IDBP-90506.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17A

Protein Name

interleukin 17A

Synonyms

CTLA8; IL-17; IL-17A; IL17;

Species

Homo sapiens

Ensembl Protein

ENSP00000344192

InnateDB Gene

IDBG-90504 (IL17A)

Protein Structure

UniProt Annotation

Function

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Restricted to activated memory T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0006486	protein glycosylation
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0008219	cell death
GO:0032747	positive regulation of interleukin-23 production
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071347	cellular response to interleukin-1
GO:0072537	fibroblast activation
GO:1900017	positive regulation of cytokine production involved in inflammatory response