InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CEL

Summary

InnateDB Protein

IDBP-90636.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEL

Protein Name

carboxyl ester lipase (bile salt-stimulated lipase)

Synonyms

BAL; BSDL; BSSL; CEase; CELL; FAP; FAPP; LIPA; MODY8;

Species

Homo sapiens

Ensembl Protein

ENSP00000342217

InnateDB Gene

IDBG-90630 (CEL)

Protein Structure

UniProt Annotation

Function

Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.

Subcellular Localization

Secreted.

Disease Associations

Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8) [MIM:609812]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin- independence at the beginning of the disease. {ECO:0000269PubMed:16369531}. Note=The disease is caused by mutations affecting the gene represented in this entry. The disease can be caused by frameshift deletions in the variable number of tandem repeats (VNTR)-containing exon 11 of the CEL gene (PubMed:16369531). {ECO:0000269PubMed:16369531}.

Tissue Specificity

Mammary gland and pancreas. Expressed by eosinophils. {ECO:0000269PubMed:11834744}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004771	sterol esterase activity
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016787	hydrolase activity
GO:0047372	acylglycerol lipase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006707	cholesterol catabolic process
GO:0008152	metabolic process
GO:0009062	fatty acid catabolic process
GO:0018350	protein esterification
GO:0030157	pancreatic juice secretion
GO:0030299	intestinal cholesterol absorption
GO:0044241	lipid digestion
GO:0044258	intestinal lipid catabolic process
GO:0044281	small molecule metabolic process