InnateDB Protein
|
IDBP-90836.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GBGT1
|
Protein Name
|
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000361113
|
InnateDB Gene
|
IDBG-90834 (GBGT1)
|
Protein Structure
|
|
Function |
Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens.
|
Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Expressed at higher level in placenta, ovary and peripheral blood leukocyte, whereas it is weakly expressed in liver, thymus, and testis. {ECO:0000269PubMed:10506200}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0016758
|
transferase activity, transferring hexosyl groups
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR005076
Glycosyl transferase, family 6
IPR029044
Nucleotide-diphospho-sugar transferases
|
PFAM |
PF03414
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8N5D6
|
PhosphoSite |
PhosphoSite-Q8N5D6
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
26301
|
UniGene |
Hs.495419
|
RefSeq |
NP_001269558
|
HUGO |
HGNC:20460
|
OMIM |
606074
|
CCDS |
CCDS65176
|
HPRD |
16193
|
IMGT |
|
EMBL |
AF163572
AK074639
AK291498
AK303825
AK314097
AL162417
AY358175
BC032499
CH471090
DQ145941
|
GenPept |
AAF06145
AAH32499
AAQ88542
AAZ38721
BAC11106
BAF84187
BAG36792
BAH14061
CAI13418
CAI13420
EAW88045
|
|
|