Version 5.4
Homo sapiens Gene: GBGT1
Summary
InnateDB Gene IDBG-90834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBGT1
Gene Name globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148288
Encoded Proteins
IDBP-90836
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
IDBP-90838
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
IDBP-90840
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
IDBP-90842
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
IDBP-601985
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:133152948-133163945
Strand Reverse strand
Band q34.2
Transcripts
ENST00000372043 ENSP00000361113
ENST00000372040 ENSP00000361110
ENST00000372038 ENSP00000361108
ENST00000372036 ENSP00000361106
ENST00000470431
ENST00000472281
ENST00000487864
ENST00000540636 ENSP00000437663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016758 transferase activity, transferring hexosyl groups
GO:0046872 metal ion binding
GO:0047277 globoside alpha-N-acetylgalactosaminyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0009247 glycolipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000026829
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000030319
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa00603
Glycosphingolipid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q5T7U8
UniProt Splice Variant
Entrez Gene 26301
UniGene Hs.495419
RefSeq NM_001282629 NM_001288572 NM_021996 NM_001282632 NM_001288573
HUGO HGNC:20460
OMIM 606074
CCDS CCDS65176 CCDS6960 CCDS65175
HPRD 16193
IMGT
EMBL AL162417
GenPept
RNA Seq Atlas 26301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca