Version 5.4
Homo sapiens Protein: GBGT1
Summary
InnateDB Protein IDBP-90838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBGT1
Protein Name globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361110
InnateDB Gene IDBG-90834 (GBGT1)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at higher level in placenta, ovary and peripheral blood leukocyte, whereas it is weakly expressed in liver, thymus, and testis. {ECO:0000269PubMed:10506200}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016758 transferase activity, transferring hexosyl groups
GO:0046872 metal ion binding
GO:0047277 globoside alpha-N-acetylgalactosaminyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0009247 glycolipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005076 Glycosyl transferase, family 6
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF03414
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N5D6
PhosphoSite PhosphoSite-Q8N5D6
TrEMBL J7Q0Z1
UniProt Splice Variant
Entrez Gene 26301
UniGene Hs.495419
RefSeq NP_068836
HUGO HGNC:20460
OMIM 606074
CCDS CCDS6960
HPRD 16193
IMGT
EMBL AF163572 AK074639 AK291498 AK303825 AK314097 AL162417 AY358175 BC032499 CH471090 DQ145941 HE583596 HE583599
GenPept AAF06145 AAH32499 AAQ88542 AAZ38721 BAC11106 BAF84187 BAG36792 BAH14061 CAI13418 CAI13420 CCD30587 CCD30590 EAW88045

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca