InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRLHR

Summary

InnateDB Protein

IDBP-90934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRLHR

Protein Name

prolactin releasing hormone receptor

Synonyms

GPR10; GR3; PrRPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000239032

InnateDB Gene

IDBG-90930 (PRLHR)

Protein Structure

UniProt Annotation

Function

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Only detected in the pituitary gland and in all cell types of pituitary adenomas. {ECO:0000269PubMed:10498338, ECO:0000269PubMed:11923475}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity
GO:0005515	protein binding
GO:0008188	neuropeptide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007565	female pregnancy
GO:0007631	feeding behavior
GO:0042445	hormone metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001402 Prolactin-releasing peptide receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01018

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49683