InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCM1

Summary

InnateDB Protein

IDBP-90992.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCM1

Protein Name

glial cells missing homolog 1 (Drosophila)

Synonyms

GCMA; hGCMa;

Species

Homo sapiens

Ensembl Protein

ENSP00000259803

InnateDB Gene

IDBG-90990 (GCM1)

Protein Structure

UniProt Annotation

Function

Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00245}.

Disease Associations

Tissue Specificity

Placenta specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009653	anatomical structure morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060018	astrocyte fate commitment
GO:0060143	positive regulation of syncytium formation by plasma membrane fusion
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060706	cell differentiation involved in embryonic placenta development