Homo sapiens Gene: GCM1
Summary
InnateDB Gene IDBG-90990.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCM1
Gene Name glial cells missing homolog 1 (Drosophila)
Synonyms GCMA; hGCMa;
Species Homo sapiens
Ensembl Gene ENSG00000137270
Encoded Proteins
glial cells missing homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:53126964-53148829
Strand Reverse strand
Band p12.1
Transcripts
ENST00000259803 ENSP00000259803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060018 astrocyte fate commitment
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060706 cell differentiation involved in embryonic placenta development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9NP62
TrEMBL
UniProt Splice Variant
Entrez Gene 8521
UniGene Hs.28346
RefSeq NM_003643
HUGO HGNC:4197
OMIM 603715
CCDS CCDS4950
HPRD 04757
IMGT
EMBL AB026493 AB041714 AB041716 AB047819 AL512347 BC096288 D88613
GenPept AAH96288 BAA13651 BAA77250 BAA94757 BAA94758 BAB18039
RNA Seq Atlas 8521