InnateDB Protein
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IDBP-90998.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELOVL5
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Protein Name
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ELOVL fatty acid elongase 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306640
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InnateDB Gene
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IDBG-90996 (ELOVL5)
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Protein Structure
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Function |
Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. {ECO:0000269PubMed:10970790, ECO:0000269PubMed:20937905}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:20937905}; Multi-pass membrane protein {ECO:0000269PubMed:20937905}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. {ECO:0000269PubMed:10970790, ECO:0000269PubMed:20937905}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006636
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unsaturated fatty acid biosynthetic process
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GO:0019432
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triglyceride biosynthetic process
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GO:0033559
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unsaturated fatty acid metabolic process
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GO:0034625
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fatty acid elongation, monounsaturated fatty acid
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GO:0034626
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fatty acid elongation, polyunsaturated fatty acid
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GO:0035338
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long-chain fatty-acyl-CoA biosynthetic process
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GO:0036109
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alpha-linolenic acid metabolic process
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GO:0042761
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very long-chain fatty acid biosynthetic process
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GO:0043651
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linoleic acid metabolic process
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR002076
GNS1/SUR4 membrane protein
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PFAM |
PF01151
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NYP7
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PhosphoSite |
PhosphoSite-Q9NYP7
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TrEMBL |
A0A024RD61
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UniProt Splice Variant |
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Entrez Gene |
60481
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UniGene |
Hs.741463
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RefSeq |
NP_068586
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HUGO |
HGNC:21308
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OMIM |
611805
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CCDS |
CCDS4951
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HPRD |
13268
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IMGT |
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EMBL |
AB209798
AF111849
AF231981
AF338241
AK074748
AK074889
AK302948
AL034374
AL136939
BC017270
BC067123
BC074503
CH471081
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GenPept |
AAF16688
AAF70631
AAH17270
AAH67123
AAM00193
BAC11178
BAC11270
BAD93035
BAG64104
CAB66873
CAI21530
CAI21531
EAX04413
EAX04414
EAX04416
EAX04418
EAX04419
EAX04421
EAX04422
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