InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6AP1

Summary

InnateDB Protein

IDBP-91426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6AP1

Protein Name

ATPase, H+ transporting, lysosomal accessory protein 1

Synonyms

16A; Ac45; ATP6IP1; ATP6S1; CF2; VATPS1; XAP-3; XAP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000358777

InnateDB Gene

IDBG-91424 (ATP6AP1)

Protein Structure

UniProt Annotation

Function

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}.

Subcellular Localization

Vacuole membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0045669	positive regulation of osteoblast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045851	pH reduction
GO:0045921	positive regulation of exocytosis
GO:0051656	establishment of organelle localization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005774	vacuolar membrane
GO:0016021	integral component of membrane
GO:0016469	proton-transporting two-sector ATPase complex
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome