Homo sapiens Gene: ATP6AP1 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Gene | IDBG-91424.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ATP6AP1 | ||||||||||||||||||
Gene Name | ATPase, H+ transporting, lysosomal accessory protein 1 | ||||||||||||||||||
Synonyms | 16A; Ac45; ATP6IP1; ATP6S1; CF2; VATPS1; XAP-3; XAP3 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000071553 | ||||||||||||||||||
Encoded Proteins |
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
ATPase, H+ transporting, lysosomal accessory protein 1
|
||||||||||||||||||
Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq, Jul 2008] This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013] |
||||||||||||||||||
Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome X:154428632-154436516 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q28 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Transferrin endocytosis and recycling pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signaling by Insulin receptor pathway
Transmembrane transport of small molecules pathway
Signal Transduction pathway
|
||||||||||||||||||
KEGG |
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Oxidative phosphorylation pathway
Lysosome pathway
Phagosome pathway
|
||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.6551 | ||||||||||||||||||
RefSeq | NM_001183 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS35451 | ||||||||||||||||||
HPRD | 02184 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||