Version 5.4
Homo sapiens Gene: ATP6AP1
Summary
InnateDB Gene IDBG-91424.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6AP1
Gene Name ATPase, H+ transporting, lysosomal accessory protein 1
Synonyms 16A; Ac45; ATP6IP1; ATP6S1; CF2; VATPS1; XAP-3; XAP3
Species Homo sapiens
Ensembl Gene ENSG00000071553
Encoded Proteins
IDBP-91426
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-383656
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-383657
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-383661
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-383663
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-383668
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-383671
ATPase, H+ transporting, lysosomal accessory protein 1
IDBP-811473
ATPase, H+ transporting, lysosomal accessory protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq, Jul 2008]
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154428632-154436516
Strand Forward strand
Band q28
Transcripts
ENST00000369762 ENSP00000358777
ENST00000422890 ENSP00000398511
ENST00000449556 ENSP00000392375
ENST00000439372 ENSP00000408317
ENST00000446552 ENSP00000411209
ENST00000455205 ENSP00000396643
ENST00000429585 ENSP00000408470
ENST00000491569
ENST00000484908
ENST00000619046 ENSP00000482243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0017137 Rab GTPase binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0045669 positive regulation of osteoblast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045851 pH reduction
GO:0045921 positive regulation of exocytosis
GO:0051656 establishment of organelle localization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:2001206 positive regulation of osteoclast development
Cellular Component
GO:0005774 vacuolar membrane
GO:0016021 integral component of membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019087
View Gene Order
ENSBTAG00000012117
Not yet available
Pathways
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_1109
Insulin receptor recycling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa00190
Oxidative phosphorylation pathway
hsa04142
Lysosome pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.6551
RefSeq NM_001183
HUGO
OMIM
CCDS CCDS35451
HPRD 02184
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca