Version 5.4
Homo sapiens Protein: FCN2
Summary
InnateDB Protein IDBP-91821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCN2
Protein Name ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
Synonyms EBP-37; FCNL; ficolin-2; P35;
Species Homo sapiens
Ensembl Protein ENSP00000291744
InnateDB Gene IDBG-91819 (FCN2)
Protein Structure
UniProt Annotation
Function May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269PubMed:10679061}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0006956 complement activation
GO:0008228 opsonization
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat
PFAM PF00147
PF01391
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15485
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 2220
UniGene
RefSeq NP_004099
HUGO HGNC:3624
OMIM 601624
CCDS CCDS6983
HPRD 03376
IMGT
EMBL AK290843 AL603650 BC069572 BC069825 CH471090 D49353 D63160 DQ217935
GenPept AAH69572 AAH69825 ABB01005 BAA08352 BAA09636 BAF83532 CAI39861 EAW88133 EAW88135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca