Version 5.4
Homo sapiens Protein: FCN1
Summary
InnateDB Protein IDBP-91831.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCN1
Protein Name ficolin (collagen/fibrinogen domain containing) 1
Synonyms FCNM;
Species Homo sapiens
Ensembl Protein ENSP00000360871
InnateDB Gene IDBG-91827 (FCN1)
Protein Structure
UniProt Annotation
Function Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269PubMed:20032467, ECO:0000269PubMed:21037097}.
Subcellular Localization Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Disease Associations
Tissue Specificity Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269PubMed:20400674}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0006956 complement activation
GO:0008228 opsonization
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat
PFAM PF00147
PF01391
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00602
PhosphoSite PhosphoSite-
TrEMBL Q92531
UniProt Splice Variant
Entrez Gene 2219
UniGene
RefSeq NP_001994
HUGO HGNC:3623
OMIM 601252
CCDS CCDS6985
HPRD 03153
IMGT
EMBL AK314867 AL353611 BC020635 CH471090 D63394 D83920 S80990
GenPept AAB50706 AAH20635 BAA09707 BAA12120 BAG37382 CAH73911 EAW88137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca