Version 5.4
Homo sapiens Protein: ARHGEF10L
Summary
InnateDB Protein IDBP-91888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF10L
Protein Name Rho guanine nucleotide exchange factor (GEF) 10-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355060
InnateDB Gene IDBG-91886 (ARHGEF10L)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269PubMed:16112081}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16112081}.
Disease Associations
Tissue Specificity Detected in heart, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:16112081}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR017986 WD40-repeat-containing domain
PFAM PF00621
PRINTS
PIRSF
SMART SM00325
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCE6
PhosphoSite PhosphoSite-Q9HCE6
TrEMBL
UniProt Splice Variant
Entrez Gene 55160
UniGene
RefSeq NP_060595
HUGO HGNC:25540
OMIM 612494
CCDS CCDS182
HPRD 07679
IMGT
EMBL AB046846 AK001383 AK092020 AL139250 AL358593 BC065561 BC080596 BC117171 BC143347 DQ139833
GenPept AAH65561 AAH80596 AAI17172 AAI43348 AAZ73162 BAA91663 BAB13452 BAC03792 CAH74135 CAH74136 CAI22139 CAI22140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca