InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DMBT1

Summary

InnateDB Protein

IDBP-91952.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMBT1

Protein Name

deleted in malignant brain tumors 1

Synonyms

GP340; muclin;

Species

Homo sapiens

Ensembl Protein

ENSP00000357951

InnateDB Gene

IDBG-91946 (DMBT1)

Protein Structure

UniProt Annotation

Function

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly- sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. {ECO:0000269PubMed:10485905, ECO:0000269PubMed:11007786, ECO:0000269PubMed:11751412, ECO:0000269PubMed:16796526, ECO:0000269PubMed:17548659, ECO:0000269PubMed:17709527, ECO:0000269PubMed:19189310, ECO:0000269PubMed:9288095}.

Subcellular Localization

Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}.

Disease Associations

Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.

Tissue Specificity

Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract. {ECO:0000269PubMed:10485905, ECO:0000269PubMed:10749143, ECO:0000269PubMed:11751412, ECO:0000269PubMed:16796526, ECO:0000269PubMed:17548659, ECO:0000269PubMed:17983803, ECO:0000269PubMed:9288095}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0008329	signaling pattern recognition receptor activity
GO:0035375	zymogen binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0006898	receptor-mediated endocytosis
GO:0015031	protein transport
GO:0016032	viral process
GO:0030855	epithelial cell differentiation
GO:0043152	induction of bacterial agglutination
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0019898	extrinsic component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0042589	zymogen granule membrane
GO:0070062	extracellular vesicular exosome