Homo sapiens Protein: DMBT1
InnateDB Protein IDBP-91964.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMBT1
Protein Name deleted in malignant brain tumors 1
Synonyms GP340; muclin;
Species Homo sapiens
Ensembl Protein ENSP00000343175
InnateDB Gene IDBG-91946 (DMBT1)
Protein Structure
UniProt Annotation
Function May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly- sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. {ECO:0000269PubMed:10485905, ECO:0000269PubMed:11007786, ECO:0000269PubMed:11751412, ECO:0000269PubMed:16796526, ECO:0000269PubMed:17548659, ECO:0000269PubMed:17709527, ECO:0000269PubMed:19189310, ECO:0000269PubMed:9288095}.
Subcellular Localization Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}.
Disease Associations Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.
Tissue Specificity Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract. {ECO:0000269PubMed:10485905, ECO:0000269PubMed:10749143, ECO:0000269PubMed:11751412, ECO:0000269PubMed:16796526, ECO:0000269PubMed:17548659, ECO:0000269PubMed:17983803, ECO:0000269PubMed:9288095}.
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0008329 signaling pattern recognition receptor activity
GO:0035375 zymogen binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0015031 protein transport
GO:0016032 viral process
GO:0030855 epithelial cell differentiation
GO:0043152 induction of bacterial agglutination
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0042589 zymogen granule membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR000859 CUB domain
IPR001190 SRCR domain
IPR001507 Zona pellucida domain
IPR017448 SRCR-like domain
PFAM PF00431
Post-translational Modifications
SwissProt Q9UGM3
PhosphoSite PhosphoSite-Q9UGM3
UniProt Splice Variant
Entrez Gene 1755
UniGene Hs.279611
RefSeq XP_006717723
OMIM 601969
HPRD 03575
EMBL AB020851 AB209691 AF159456 AJ000342 AJ243211 AJ243212 AJ243224 AJ297935 AK304149 AL603764 BC153299 BX640988 FJ234410
GenPept AAD49696 AAI53300 ACI95281 BAA78577 BAD92928 BAH14118 CAA04019 CAB56155 CAB63941 CAB63942 CAC44122 CAE45995 CAI14487 CAI14488 CAI14489 CAI14490 CAI14491 CAI14492 CAI14493 CAI14494 CAI14495 CAI14496