InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNAPC4

Summary

InnateDB Protein

IDBP-92337.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAPC4

Protein Name

small nuclear RNA activating complex, polypeptide 4, 190kDa

Synonyms

PTFalpha; SNAP190;

Species

Homo sapiens

Ensembl Protein

ENSP00000298532

InnateDB Gene

IDBG-92335 (SNAPC4)

Protein Structure

UniProt Annotation

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269PubMed:12621023, ECO:0000269PubMed:9418884}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00625}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006383	transcription from RNA polymerase III promoter
GO:0009301	snRNA transcription
GO:0010467	gene expression
GO:0042795	snRNA transcription from RNA polymerase II promoter
GO:0042796	snRNA transcription from RNA polymerase III promoter