InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR3H

Summary

InnateDB Protein

IDBP-9250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR3H

Protein Name

polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347345

InnateDB Gene

IDBG-9248 (POLR3H)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0006384	transcription initiation from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005666	DNA-directed RNA polymerase III complex
GO:0005813	centrosome
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR004519 DNA-directed RNA polymerase, subunit E/RPC8
IPR005576 RNA polymerase Rpb7, N-terminal
IPR012340 Nucleic acid-binding, OB-fold
IPR013238 RNA polymerase III, subunit Rpc25

PFAM

PF03876
PF08292

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y535

PhosphoSite