InnateDB Protein
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IDBP-9252.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR3H
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000337627
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InnateDB Gene
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IDBG-9248 (POLR3H)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006139
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nucleobase-containing compound metabolic process
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GO:0006351
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transcription, DNA-templated
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GO:0006383
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transcription from RNA polymerase III promoter
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GO:0006384
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transcription initiation from RNA polymerase III promoter
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GO:0006385
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transcription elongation from RNA polymerase III promoter
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GO:0006386
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termination of RNA polymerase III transcription
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GO:0010467
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gene expression
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GO:0032481
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positive regulation of type I interferon production
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GO:0045087
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innate immune response
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GO:0051607
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defense response to virus
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Cellular Component |
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PDB ID |
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InterPro |
IPR005576
RNA polymerase Rpb7, N-terminal
IPR012340
Nucleic acid-binding, OB-fold
IPR013238
RNA polymerase III, subunit Rpc25
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PFAM |
PF03876
PF08292
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y535
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
171568
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UniGene |
Hs.712617
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RefSeq |
NP_001018062
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HUGO |
HGNC:30349
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OMIM |
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CCDS |
CCDS33651
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HPRD |
15157
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IMGT |
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EMBL |
AB051452
AL023553
AY092087
BC017248
BC088367
CH471095
CR456459
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GenPept |
AAH17248
AAH88367
AAM18217
BAB33335
CAB46023
CAG30345
CAQ10207
EAW60438
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