InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST15

Summary

InnateDB Protein

IDBP-92596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST15

Protein Name

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333947

InnateDB Gene

IDBG-92594 (CHST15)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. {ECO:0000269PubMed:11572857, ECO:0000269PubMed:12874280}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.

Disease Associations

Tissue Specificity

Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1. {ECO:0000269PubMed:9754571}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0019319	hexose biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process