InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G5

Summary

InnateDB Protein

IDBP-92816.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G5

Protein Name

phospholipase A2, group V

Synonyms

FRFB; GV-PLA2; hVPLA(2); PLA2-10;

Species

Homo sapiens

Ensembl Protein

ENSP00000364249

InnateDB Gene

IDBG-92814 (PLA2G5)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.

Subcellular Localization

Secreted.

Disease Associations

Fleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. {ECO:0000269PubMed:22137173}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level). {ECO:0000269PubMed:22137173}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0008201	heparin binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006663	platelet activating factor biosynthetic process
GO:0016042	lipid catabolic process
GO:0019370	leukotriene biosynthetic process
GO:0034097	response to cytokine
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050482	arachidonic acid secretion
GO:0051591	response to cAMP