Homo sapiens Gene: PLA2G5
Summary
InnateDB Gene IDBG-92814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G5
Gene Name phospholipase A2, group V
Synonyms FRFB; GV-PLA2; hVPLA(2); PLA2-10;
Species Homo sapiens
Ensembl Gene ENSG00000127472
Encoded Proteins
phospholipase A2, group V
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20028179-20091190
Strand Forward strand
Band p36.13
Transcripts
ENST00000375108 ENSP00000364249
ENST00000486277
ENST00000465698
ENST00000460175
ENST00000469069
ENST00000489871
ENST00000498348
ENST00000478803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008201 heparin binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006663 platelet activating factor biosynthetic process
GO:0016042 lipid catabolic process
GO:0019370 leukotriene biosynthetic process
GO:0034097 response to cytokine
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0050482 arachidonic acid secretion
GO:0051591 response to cAMP
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Acyl chain remodelling of PS pathway
Metabolism of lipids and lipoproteins pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Metabolism pathway
Acyl chain remodelling of PI pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.319438 Hs.733276
RefSeq NM_000929 XM_005245893 XM_005245895 XM_005245896 XM_006710692 XM_006710693 XM_006710694 XM_006710695 XM_006710696
HUGO
OMIM
CCDS CCDS202
HPRD 03117
IMGT
EMBL
GenPept
RNA Seq Atlas