InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4G3

Summary

InnateDB Protein

IDBP-93023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4G3

Protein Name

eukaryotic translation initiation factor 4 gamma, 3

Synonyms

eIF-4G 3; eIF4G 3; eIF4GII;

Species

Homo sapiens

Ensembl Protein

ENSP00000264211

InnateDB Gene

IDBG-93019 (EIF4G3)

Protein Structure

UniProt Annotation

Function

Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. {ECO:0000269PubMed:9418880}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway