InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRIN1

Summary

InnateDB Protein

IDBP-93087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN1

Protein Name

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Synonyms

GluN1; MRD8; NMDA1; NMDAR1; NR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000360610

InnateDB Gene

IDBG-93071 (GRIN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity

Biological Process

GO:0006810	transport
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10562
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt