InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IBTK

Summary

InnateDB Protein

IDBP-93671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IBTK

Protein Name

inhibitor of Bruton agammaglobulinemia tyrosine kinase

Synonyms

BTBD26; BTKI;

Species

Homo sapiens

Ensembl Protein

ENSP00000305721

InnateDB Gene

IDBG-93669 (IBTK)

Protein Structure

UniProt Annotation

Function

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269PubMed:11577348}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. {ECO:0000269PubMed:11577348, ECO:0000269PubMed:18596081}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030292	protein tyrosine kinase inhibitor activity

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0061099	negative regulation of protein tyrosine kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR000408 Regulator of chromosome condensation, RCC1
IPR002110 Ankyrin repeat
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00415
PF00023
PF13606
PF00651
PF11929
PF12796

PRINTS

PR00633
PR01415

PIRSF

SMART

SM00225
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt