Version 5.4
Homo sapiens Gene: IBTK
Summary
InnateDB Gene IDBG-93669.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IBTK
Gene Name inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms BTBD26; BTKI
Species Homo sapiens
Ensembl Gene ENSG00000005700
Encoded Proteins
IDBP-93671
inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDBP-482422
inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDBP-484394
inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDBP-477706
inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDBP-479764
inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDBP-813574
inhibitor of Bruton agammaglobulinemia tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. [provided by RefSeq, Jul 2008]
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK\'s kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:82169983-82247754
Strand Reverse strand
Band q14.1
Transcripts
ENST00000306270 ENSP00000305721
ENST00000369751
ENST00000445419
ENST00000505222
ENST00000508381
ENST00000503400 ENSP00000422136
ENST00000503631 ENSP00000422762
ENST00000510291 ENSP00000426405
ENST00000471036 ENSP00000424634
ENST00000610980 ENSP00000478891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030292 protein tyrosine kinase inhibitor activity
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0051209 release of sequestered calcium ion into cytosol
GO:0061099 negative regulation of protein tyrosine kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035941
View Gene Order
ENSBTAG00000026716
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.306425 Hs.604934
RefSeq NM_001300906 NM_015525 XM_006715454 XM_006715455
HUGO
OMIM
CCDS CCDS34490 CCDS75486
HPRD 12105
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca