InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ECHS1

Summary

InnateDB Protein

IDBP-93746.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ECHS1

Protein Name

enoyl CoA hydratase, short chain, 1, mitochondrial

Synonyms

SCEH;

Species

Homo sapiens

Ensembl Protein

ENSP00000357535

InnateDB Gene

IDBG-93744 (ECHS1)

Protein Structure

UniProt Annotation

Function

Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Liver, fibroblast, muscle. Barely detectable in spleen and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004300	enoyl-CoA hydratase activity
GO:0005515	protein binding

Biological Process

GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001753 Crotonase superfamily
IPR029045 ClpP/crotonase-like domain

PFAM

PF00378

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30084

PhosphoSite

PhosphoSite-P30084

TrEMBL

UniProt Splice Variant

Entrez Gene

1892

UniGene

Hs.76394

RefSeq

NP_004083

HUGO

HGNC:3151

OMIM

602292

CCDS

CCDS7681

HPRD

03799

IMGT

EMBL

AL360181 BC008906 BT007123 D13900 X98126 X98127 X98128 X98129

GenPept

AAH08906 AAP35787 BAA03001 CAA66808 CAH70286