InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLIC4

Summary

InnateDB Protein

IDBP-94254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIC4

Protein Name

chloride intracellular channel 4

Synonyms

CLIC4L; H1; huH1; MTCLIC; p64H1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363500

InnateDB Gene

IDBG-94252 (CLIC4)

Protein Structure

UniProt Annotation

Function

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269PubMed:12163372, ECO:0000269PubMed:14569596, ECO:0000269PubMed:16176272, ECO:0000269PubMed:16239224, ECO:0000269PubMed:18302930, ECO:0000269PubMed:19247789}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Disease Associations

Tissue Specificity

Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269PubMed:10793131, ECO:0000269PubMed:17200346, ECO:0000269PubMed:17636002}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001886	endothelial cell morphogenesis
GO:0006821	chloride transport
GO:0007035	vacuolar acidification
GO:0009566	fertilization
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0030336	negative regulation of cell migration
GO:0034765	regulation of ion transmembrane transport
GO:0035088	establishment or maintenance of apical/basal cell polarity
GO:0035264	multicellular organism growth
GO:0044070	regulation of anion transport
GO:0048754	branching morphogenesis of an epithelial tube
GO:0051493	regulation of cytoskeleton organization
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0071277	cellular response to calcium ion
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030496	midbody
GO:0030659	cytoplasmic vesicle membrane
GO:0034707	chloride channel complex
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome