InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLIC4

Summary

InnateDB Gene

IDBG-94252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIC4

Gene Name

chloride intracellular channel 4

Synonyms

CLIC4L; H1; huH1; MTCLIC; p64H1

Species

Homo sapiens

Ensembl Gene

ENSG00000169504

Encoded Proteins

IDBP-94254

chloride intracellular channel 4

IDBP-593887

chloride intracellular channel 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:24745357-24844324

Strand

Forward strand

Band

p36.11

Transcripts

ENST00000374379	ENSP00000363500
ENST00000488683	ENSP00000436538
ENST00000497755
ENST00000489758

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001886	endothelial cell morphogenesis
GO:0006821	chloride transport
GO:0007035	vacuolar acidification
GO:0009566	fertilization
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0030336	negative regulation of cell migration
GO:0034765	regulation of ion transmembrane transport
GO:0035088	establishment or maintenance of apical/basal cell polarity
GO:0035264	multicellular organism growth
GO:0044070	regulation of anion transport
GO:0048754	branching morphogenesis of an epithelial tube
GO:0051493	regulation of cytoskeleton organization
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0071277	cellular response to calcium ion
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030496	midbody
GO:0030659	cytoplasmic vesicle membrane
GO:0034707	chloride channel complex
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037242

View Gene Order

ENSBTAG00000009470

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.440544 Hs.592249 Hs.602330 Hs.611641

RefSeq

NM_013943

HUGO

OMIM

CCDS

CCDS256

HPRD

05943

IMGT

EMBL

GenPept

RNA Seq Atlas