Homo sapiens Gene: CLIC4
Summary
InnateDB Gene IDBG-94252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC4
Gene Name chloride intracellular channel 4
Synonyms CLIC4L; H1; huH1; MTCLIC; p64H1;
Species Homo sapiens
Ensembl Gene ENSG00000169504
Encoded Proteins
chloride intracellular channel 4
chloride intracellular channel 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:24745357-24844324
Strand Forward strand
Band p36.11
Transcripts
ENST00000374379 ENSP00000363500
ENST00000488683 ENSP00000436538
ENST00000497755
ENST00000489758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0006821 chloride transport
GO:0007035 vacuolar acidification
GO:0009566 fertilization
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0034765 regulation of ion transmembrane transport
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035264 multicellular organism growth
GO:0044070 regulation of anion transport
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051493 regulation of cytoskeleton organization
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0071277 cellular response to calcium ion
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030496 midbody
GO:0030659 cytoplasmic vesicle membrane
GO:0034707 chloride channel complex
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9Y696
TrEMBL B4DWC4 Q6FIC5
UniProt Splice Variant
Entrez Gene 25932
UniGene Hs.440544 Hs.592249 Hs.602330 Hs.611641
RefSeq NM_013943
HUGO HGNC:13518
OMIM 606536
CCDS CCDS256
HPRD 05943
IMGT
EMBL AF097330 AF109196 AK301466 AK315051 AL117424 BC012444 CH471134 CR533501
GenPept AAD26136 AAD38446 AAH12444 BAG37528 BAG62986 CAB55916 CAG38532 EAW95143 EAW95144 EAW95145 EAW95146
RNA Seq Atlas 25932