InnateDB Protein
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IDBP-94428.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STMN1
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Protein Name
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stathmin 1
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Synonyms
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C1orf215; Lag; LAP18; OP18; PP17; PP19; PR22; SMN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000350531
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InnateDB Gene
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IDBG-94424 (STMN1)
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Protein Structure
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Function |
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. {ECO:0000269PubMed:12676564, ECO:0000269PubMed:1917919}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000956
Stathmin family
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PFAM |
PF00836
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PRINTS |
PR00345
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PIRSF |
PIRSF002285
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P16949
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PhosphoSite |
PhosphoSite-P16949
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TrEMBL |
A2A2D0
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UniProt Splice Variant |
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Entrez Gene |
3925
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UniGene |
Hs.714380
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RefSeq |
NP_981944
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HUGO |
HGNC:6510
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OMIM |
151442
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CCDS |
CCDS269
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HPRD |
01047
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IMGT |
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EMBL |
AK303692
AK311801
AL033528
BC082228
CH471059
J04991
M31303
X53305
X94912
Z11566
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GenPept |
AAA59971
AAA59980
AAH82228
BAG34744
BAH14020
CAA37391
CAA64398
CAA77660
CAC16020
EAX07854
EAX07855
EAX07856
EAX07857
EAX07858
EAX07859
EAX07860
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