InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM63

Summary

InnateDB Protein

IDBP-94468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM63

Protein Name

tripartite motif containing 63

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363390

InnateDB Gene

IDBG-94466 (TRIM63)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269PubMed:11927605, ECO:0000269PubMed:18222470}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.

Disease Associations

Tissue Specificity

Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269PubMed:11243782, ECO:0000269PubMed:11283016, ECO:0000269PubMed:11679633, ECO:0000269PubMed:12107412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031432	titin binding
GO:0046872	metal ion binding

Biological Process

GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0010468	regulation of gene expression
GO:0014732	skeletal muscle atrophy
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051384	response to glucocorticoid
GO:0070555	response to interleukin-1
GO:0071549	cellular response to dexamethasone stimulus