InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU3F2

Summary

InnateDB Protein

IDBP-94514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU3F2

Protein Name

POU class 3 homeobox 2

Synonyms

brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7; OTF7; POUF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000329170

InnateDB Gene

IDBG-94512 (POU3F2)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed specifically in the neuroectodermal cell lineage.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0014002	astrocyte development
GO:0014044	Schwann cell development
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021869	forebrain ventricular zone progenitor cell division
GO:0021979	hypothalamus cell differentiation
GO:0021985	neurohypophysis development
GO:0022011	myelination in peripheral nervous system
GO:0030182	neuron differentiation
GO:0040018	positive regulation of multicellular organism growth
GO:0045595	regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050770	regulation of axonogenesis
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000327 POU-specific
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain
IPR016362 Transcription factor, homeobox/POU

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00028

PIRSF

PIRSF002629

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References