Version 5.4
Homo sapiens Gene: POU3F2
Summary
InnateDB Gene IDBG-94512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU3F2
Gene Name POU class 3 homeobox 2
Synonyms brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7; OTF7; POUF3
Species Homo sapiens
Ensembl Gene ENSG00000184486
Encoded Proteins
IDBP-94514
POU class 3 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:98834592-98839490
Strand Forward strand
Band q16.1
Transcripts
ENST00000328345 ENSP00000329170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0014002 astrocyte development
GO:0014044 Schwann cell development
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021869 forebrain ventricular zone progenitor cell division
GO:0021979 hypothalamus cell differentiation
GO:0021985 neurohypophysis development
GO:0022011 myelination in peripheral nervous system
GO:0030182 neuron differentiation
GO:0040018 positive regulation of multicellular organism growth
GO:0045595 regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050770 regulation of axonogenesis
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
ENSBTAG00000024773
Not yet available
ENSMUSG00000095139
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.182505 Hs.544498 Hs.740556 Hs.741038
RefSeq NM_005604
HUGO
OMIM
CCDS CCDS5040
HPRD 02734
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca