Homo sapiens Gene: POU3F2
Summary
InnateDB Gene IDBG-94512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU3F2
Gene Name POU class 3 homeobox 2
Synonyms brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7; OTF7; POUF3;
Species Homo sapiens
Ensembl Gene ENSG00000184486
Encoded Proteins
POU class 3 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:98834592-98839490
Strand Forward strand
Band q16.1
Transcripts
ENST00000328345 ENSP00000329170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0014002 astrocyte development
GO:0014044 Schwann cell development
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021869 forebrain ventricular zone progenitor cell division
GO:0021979 hypothalamus cell differentiation
GO:0021985 neurohypophysis development
GO:0022011 myelination in peripheral nervous system
GO:0030182 neuron differentiation
GO:0040018 positive regulation of multicellular organism growth
GO:0045595 regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050770 regulation of axonogenesis
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt P20265
TrEMBL
UniProt Splice Variant
Entrez Gene 5454
UniGene Hs.182505 Hs.544498 Hs.740556 Hs.741038
RefSeq NM_005604
HUGO HGNC:9215
OMIM 600494
CCDS CCDS5040
HPRD 02734
IMGT
EMBL AL022395 BC051699 L37868 Z11933
GenPept AAB59611 AAH51699 CAA77990 CAB37982
RNA Seq Atlas 5454